Study M322
Study name | Zhang YF 2015 |
Title | A MRS study of metabolic alterations in the frontal white matter of major depressive disorder patients with the treatment of SSRIs |
Overall design | This study focused on the observation of any potential changes in the metabolite levels of the ventral prefrontal white matter in major depressive disorder (MDD) patients who have received antidepressant treatment. Female patients diagnosed as MDD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria with the scores of 18 and above on the 24-item Hamilton Depression Rating Scale (HDRS) were recruited (depression group, n = 17). In addition, healthy volunteers were recruited as normal control (control group, n = 19). Proton magnetic resonance spectroscopy (1H-MRS)scanning was performed on both control and patient groups before SSRIs treatment. The patient group received the second MRS examination about 12 weeks after applying paroxetine treatment (20 mg/d). MRS studies were performed on a 3.0 T MR system, single voxel PRESS spectroscopy with chemical-shift selective saturation water suppression. The volume of interest was localized at the bilateral ventral prefrontal white matter regions (voxel size: 2 x 2 x 2 mm(3)). The spectral data analysis was performed by using the instrument manufacturer supplied software. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-24 >= 18 |
Sample size | 36 |
Tissue | Central; Brain; Ventral prefrontal white matter; |
Platform | MRS; MRS: 3.0 T MR system (General Electric, Excite Signa HD 3.0 T); |
PMID | |
DOI | |
Citation | Zhang Y, Han Y, Wang Y, et al. A MRS study of metabolic alterations in the frontal white matter of major depressive disorder patients with the treatment of SSRIs. BMC Psychiatry 2015;15:99. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
