Study M321

Study name

Jia YB 2015

Title

The correlation between biochemical abnormalities in frontal white matter, hippocampus and serum thyroid hormone levels in first-episode patients with major depressive disorder

Overall design

This study sought to investigate the relationship between the biochemical metabolism and the serum thyroid hormone levels in first-episode, treatment-naive, non-late-life patients with major depressive disorder (MDD). First-episode, treatment-naive, non-late-life patients with MDD (depression group, n = 26) and healthy controls (control group, n = 13) were enrolled in this study. Participants underwent two-dimensinal multivoxel proton magnetic resonance spectroscopy (1H MRS) [repetition time (TR) = 1000 ms; echo-time (TE) = 144 ms] at 1.5 T to obtain bilateral metabolite levels from the white matter in prefrontal (WMP) lobe, anterior cingulate cortex (ACC), and hippocampus. The ratios of N-acetylaspartate (NAA)/creatine (Cr) and choline containg compounds (Cho)/creatine (Cr) were calculated.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD, HAMD-17 >= 18

Sample size

39

Tissue

Central; Brain; Anterior cingulate cortex;

Central; Brain; Prefrontal lobe white matter;

Central; Brain; Hippocampus;

Platform

MRS; MRS: 1.5 T GE Signa MR system (General Electric, Milwaukee, WI, USA);

PMID

25913802

DOI

10.1016/j.jad.2015.04.005

Citation

Jia Y, Zhong S, Wang Y, et al. The correlation between biochemical abnormalities in frontal white matter, hippocampus and serum thyroid hormone levels in first-episode patients with major depressive disorder. J Affect Disord. 2015;180:162-9.

Metabolite

N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio;

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;