Study M320
Study name | Zheng HR 2015 |
Title | Abnormal anterior cingulate N-Acetylaspartate and executive functioning in treatment-resistant depression after rTMS therapy |
Overall design | In this study, cognitive deficits and altered biochemical signals were examined in pre- and post-repetitive transcranial magnetic stimulation (rTMS) younger adult patients with treatment-resistant depression (TRD) compared with healthy subjects. Thirty-two young depressed patients with treatment-resistant unipolar depression (depression group, n = 32) were enrolled in a double-blind, randomized study [rTMS group (n = 18) vs. sham rTMS group (n = 14)]. Anterior cingulate cortex (ACC) metabolism was investigated before and after 4 weeks of high-frequency (15 Hz) rTMS using 3-tesla proton magnetic resonance spectroscopy (1H-MRS). The results were compared with age- and gender-matched healthy controls (control group, n = 28). Executive functioning was measured with the Wisconsin Card Sorting Test (WCST) among 34 subjects with TRD and 28 healthy subjects. Response was defined as a 50% reduction in the HAMD score. A total of 11 out of 18 patients responded to active rTMS treatment (rTMS responder group) and 1 of 14 patients responded to sham rTMS treatment (sham rTMS responder group). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 60 |
Tissue | Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: 3.0 Tesla Siemens whole body imaging system (3.0 T, Trio Tim); |
PMID | |
DOI | |
Citation | Zheng H, Jia F, Guo G, et al. Abnormal anterior cingulate N-Acetylaspartate and executive functioning in treatment-resistant depression after rTMS therapy. Int J Neuropsychopharmacol 2015;18(11):pyv059. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
