Study M319

Study name

Zhao LL 2015

Title

1H-MRS analysis for prefrontal cortex, hippocampus and thalamus of adolescent patients with depression

Overall design

The aim of this study was to explore the change of neural biochemical metabolite level in prefrontal cortex, hippocampus and thalamus of adolescent patients with depression. This study conducted multi-voxel 1H-MRS scan for encephalic regions including frontal cortex, hippocampus and thalamus of the adolescent depressed patients, and detected the contents of N-acetyl aspartate (NAA), Choline compounds (Cho), glutamic acid compounds (Glx), creatine compounds (Cr2, Cr) and myo-inositol (mI) to explore the biochemical basis for the morbidity of adolescent depression. There were a total of 30 patients at the age of 13-20 (depression group). The control group had a total of 30 healthy volunteers at the age of 13-20 (control group). Metabolite quantification was reported relative to total creatine as the reference peak.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Pediatric depression; Pediatric depression;

Criteria for depression

DSM-IV diagnosed MDD, HAMD-24 > 20

Sample size

60

Tissue

Central; Brain; Prefrontal cortex;

Central; Brain; Hippocampus;

Central; Brain; Thalamus;

Platform

MRS; MRS: Magnetom Avanto1.5 T superconductive MRI system (SIEMENS, Germany);

PMID

N/A

DOI

10.1166/jmihi.2015.1507

Citation

Zhao LL, Xiao H, Gao XL, et al. 1H-MRS analysis for prefrontal cortex, hippocampus and thalamus of adolescent patients with depression. Journal of Medical Imaging & Health Informatics 2015;5(6):1229-32.

Metabolite

N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio;

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;

myo-Inositol/(Creatine and Phosphocreatine) ratio;

(Glutamate and Glutamine)/(Creatine and Phosphocreatine) ratio;