Study M318
Study name | Lirng JF 2015 |
Title | Increased myo-inositol level in dorsolateral prefrontal cortex in migraine patients with major depression |
Overall design | The aim of this study was to investigate the relationship between brain metabolites in the dorsolateral prefrontal cortex (DLPFC) and major depressive disorder (MDD) in migraine patients using proton magnetic resonance spectroscopy (1H-MRS). Thirty migraine patients completed the study. Among them, 16 migraine patients met the diagnostic criteria for MDD (migraine with depression group), and the other 14 did not (migraine without depression group). All patients underwent a MRS examination focusing on bilateral DLPFC. The ratios of N-acetylaspartate (NAA), choline (Cho), and myo-inositol (mI) to total creatine (tCr) were compared between migraine patients with and without MDD, and were correlated with Beck Depression Inventory (BDI) scores. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression with comorbidity; Depression with comorbidity; |
Criteria for depression | DSM-IV and ICD-10 diagnosed MDD |
Sample size | 30 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; |
Platform | MRS; MRS: 1.5 T MR scanner (Signa EXCITE, GE Medical System, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | Lirng JF, Chen HC, Fuh JL, et al. Increased myo-inositol level in dorsolateral prefrontal cortex in migraine patients with major depression. Cephalalgia 2015;35(8):702-9. |
Metabolite |
