Study M316
Study name | Hermens DF 2015 |
Title | Hippocampal glutamate is increased and associated with risky drinking in young adults with major depression |
Overall design | This study aimed to determine whether risky drinking is associated with glutamate levels recorded within the hippocampus of young adults with major depression. Young persons with major depression (depression group, n = 63) and healthy controls (control group, n = 38) were recruited. Participants completed the alcohol use disorder identification test and underwent proton magnetic resonance spectroscopy to measure in vivo glutamate levels within the hippocampus following a period of at least 48 h of abstinence. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 101 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 3 Tesla GE Discovery MR750 MRI scanner (GE Medical Systems, Milwaukee, WI); |
PMID | |
DOI | |
Citation | Hermens DF, Chitty KM, Lee RS, et al. Hippocampal glutamate is increased and associated with risky drinking in young adults with major depression. J Affect Disord 2015;186:95-8. |
Metabolite |
