Study M315
Study name | Guo ZW 2015 |
Title | Neurometabolic characteristics in the anterior cingulate gyrus of Alzheimer's disease patients with depression: a 1H magnetic resonance spectroscopy study |
Overall design | The aim of this study was to identify neurometabolic characteristics in the brain that are associated with depression in patients with mild Alzheimer's disease (AD). Thirty-seven patients were evaluated using the Neuropsychiatric Inventory (NPI) and Hamilton Depression Rating Scale (HAMD-17), and divided into two groups: AD patients with depression (AD with depression group, n = 17) and non-depressed AD patients (AD without depression group, n = 20). Using proton magnetic resonance spectroscopy, neurometabolites in the anterior cingulate gyrus (ACG) of these two group patients were characterized. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Geriatric depression; Geriatric depression; Depressive disorder; Depression with comorbidity; Depression with comorbidity; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 7 |
Sample size | 37 |
Tissue | Central; Brain; Anterior cingulate gyrus; |
Platform | MRS; MRS: 3.0 Tesla unit (Siemens MAGNETOM Verio; Siemens Medical Systems, Erlangen, Germany); |
PMID | |
DOI | |
Citation | Guo Z, Zhang J, Liu X, et al. Neurometabolic characteristics in the anterior cingulate gyrus of Alzheimer's disease patients with depression: a 1H magnetic resonance spectroscopy study. BMC Psychiatry 2015;15:306. |
Metabolite |
