Study M313

Study name

Biedermann SV 2015

Title

31P RINEPT MRSI and VBM reveal alterations in brain aging associated with major depression

Overall design

Here, RINEPT and volumetric analyses using voxel based morphometry (VBM) were applied in a sample of depressed patients and matched healthy controls. Depressed in-patients were either treated with antidepressive medication or with electroconvulsive therapy and compared to matched healthy controls. 31P magnetic resonance spectroscopy imaging was conducted before and after the treatment phases. A 3D MRI dataset for volumetry was acquired in a dedicated 1H head coil. In total, 81 participants were included into the study, 46 patients suffering from a major depressive episode according to DSM-IV, of which 24 were treated with ADM and 22 with ECT, and healthy subjects (control group, n = 35). For 31P MRSI, data were compared between depression group (n = 19) and control group (n = 24) at baseline, and 14 in the depression group and 15 in the control group after treatment. Metabolite quantification was reported in institutional units.

Study Type

Type1;

Type2;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

43

Tissue

Central; Brain; Frontal cortex;

Central; Brain; Medial frontal cortex;

Central; Brain; Hippocampus;

Central; Brain; Insula;

Central; Brain; Basal ganglia;

Central; Brain; Brainstem;

Central; Brain; Cerebellar cortex;

Central; Brain; Temporal lobe;

Central; Brain; Cerebellum;

Platform

MRS; MRS: Siemens Magnetom Vision Plus 1.5 T full-body clinical scanner;

PMID

24798730

DOI

10.1002/mrm.25278

Citation

Biedermann SV, Weber-Fahr W, Demirakca T, et al. 31P RINEPT MRSI and VBM reveal alterations in brain aging associated with major depression. Magn Reson Med 2015;73(4):1390-400.

Metabolite

Phosphorylcholine;

O-Phosphoethanolamine;