Study M312
Study name | Harper DG 2014 |
Title | Tissue-specific differences in brain phosphodiesters in late-life major depression |
Overall design | The aim of this study was to measure individual membrane metabolites in subjects with late-life depression versus normal comparison subjects. Patients with late-life major depression who were medication free at time of study (depression group, n = 10) and aged normal comparison subjects (control group, n = 11) were studied using phosphorus magnetic resonance spectroscopy (31P MRS) three-dimensional chemical shift imaging at 4 Tesla. For each metabolite, the peak area was normalized by the total phosphorous signal. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Geriatric depression; Geriatric depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 18 |
Sample size | 21 |
Tissue | Central; Brain; White matter; Central; Brain; Gray matter; |
Platform | MRS; MRS: 4 Tesla MR; |
PMID | |
DOI | |
Citation | Harper DG, Jensen JE, Ravichandran C, et al. Tissue-specific differences in brain phosphodiesters in late-life major depression. Am J Geriatr Psychiatry 2014;22(5):499-509. |
Metabolite |
