Study M311
Study name | Gharraf H 2014 |
Title | Proton magnetic resonance spectroscopy of brain in obstructive sleep apnea in Egyptian subjects |
Overall design | The overall objective of this work is to study the cerebral metabolic changes in patients with obstructive sleep apnea (OSA) and to determine the usefulness of magnetic resonance spectroscopy (MRS) as an objective method for evaluation of CNS impairment in these patients. This study included two groups; including patients diagnosed with obstructive sleep apnea hypopnea syndrome (OSAHS group, n = 15), and healthy volunteers of comparable age (control group, n = 10). Magnetic resonance spectra were obtained from frontal periventricular white matter. Symptoms of anxiety and depression were measured with the Hospital Anxiety and Depression Scale (HADS). All of the studied patients (100%) had a depression subscale of Hospital Anxiety and Depression Scale core >= 11 (probable depression). Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive symptom; Depressive symptom with comorbidity; Depressive symptom with comorbidity; |
Criteria for depression | Depression subscale of Hospital Anxiety and Depression Scale core >= 11 |
Sample size | 25 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Frontal white matter; |
Platform | MRS; MRS: 1.5 Tesla MR (AVANTO, Siemens, Germany); |
PMID | |
DOI | |
Citation | Gharraf H, Matrawy K, Reda I. Proton magnetic resonance spectroscopy of brain in obstructive sleep apnea in Egyptian subjects. Egyptian Journal of Chest Diseases and Tuberculosis 2014;63(2):395-403. |
Metabolite | N-Acetyl-L-aspartic acid; N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
