Study M310
Study name | Chen LP 2014 |
Title | Anterior cingulate cortex and cerebellar hemisphere neurometabolite changes in depression treatment: a 1H magnetic resonance spectroscopy study |
Overall design | This study utilized single-voxel 1H magnetic resonance spectroscopy to determine biochemical abnormalities related to major depressive disorder (MDD) in the bilateral dorsolateral prefrontal cortex, anterior cingulate cortex (ACC), and cerebellar hemisphere before and after antidepressant treatment. Adult MDD patients (depression group, n = 15) and age- and sex-matched healthy controls (control group, n = 15) were involved. Magnetic resonance spectroscopy of the brain was conducted in all subjects at the beginning of the study and the depressed subjects were reassessed after 8 weeks of selective serotonin reuptake inhibitor (SSRI) treatment. An external standard phantom, containing detectable compounds of known concentrations, was used to calibrate the metabolite concentrations. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 17 |
Sample size | 30 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; Central; Brain; Anterior cingulate cortex; Central; Brain; Cerebellum; |
Platform | MRS; MRS: 1.5-T GE Signa HDx scanner (General Electric Medical Systems, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | Chen LP, Dai HY, Dai ZZ, et al. Anterior cingulate cortex and cerebellar hemisphere neurometabolite changes in depression treatment: a 1H magnetic resonance spectroscopy study. Psychiatry Clin Neurosci 2014;68(5):357-64. |
Metabolite |
