Study M309
Study name | Bogdanova OV 2014 |
Title | Neurochemical alterations in frontal cortex of the rat after one week of hypobaric hypoxia |
Overall design | The aim of this study was to test the hypothesis that hypobaric hypoxia is responsible for development of mood disorders due to alterations in neurochemistry. Thirty-two female Sprague Dawley rats were divided into the following 2 groups: (1) control group (housed at local conditions), and (2) hypobaric hypoxia group (housed in a hypobaric hypoxia chamber at 10,000 ft of simulated altitude for 1 week). Depression-like behavior was assessed using the forced swim test and levels of neurometabolites were estimated by in vivo proton magnetic resonance spectroscopy in the frontal cortex, the striatum and the hippocampus at baseline and after a week of exposure to hypobaric hypoxia (n = 12). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; |
Criteria for depression | Forced swimming test |
Sample size | 12 |
Tissue | Central; Brain; Frontal cortex; Central; Brain; Striatum; Central; Brain; Hippocampus; |
Platform | MRS; MRS: 7 T horizontal-bore Bruker Biospec MRI scanner (Bruker Biospin, Billerica, MA, USA); |
PMID | |
DOI | |
Citation | Bogdanova OV, Abdullah O, Kanekar S, et al. Neurochemical alterations in frontal cortex of the rat after one week of hypobaric hypoxia. Behav Brain Res 2014;263:203-9. |
Metabolite | myo-Inositol/(Creatine and Phosphocreatine) ratio; Glutamate/(Creatine and Phosphocreatine) ratio; (myo-Inositol and Glycine)/(Creatine and Phosphocreatine) ratio; |
