Study M308
Study name | Sozeri-Varma G 2013 |
Title | Neurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression |
Overall design | The aim of this study is to investigate neurochemical metabolite levels in the prefrontal cortex (PFC) of patients with mild/moderate major depressive disorder (MDD). Patients with mild MDD (mild depression group, MDD with HAMD-17 <= 15, n = 21), patients with moderate MDD (moderate depression group, MDD with HAMD-17 > 15, n = 18), and matched control subjects (control group, n = 16) participated in the study. Patients had had their first episode. They had not taken treatment. Levels of N-acetyl aspartate (NAA), choline-containing compounds (Cho), and creatine-containing compounds (Cr) were measured using proton magnetic resonance spectroscopy (1H-MRS) at 1.5 T, with an 8-cm3 single voxel placed in the right PFC. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 55 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | MRS; MRS: 1.5 Tesla magnetic resonance scanner (GE Medical Systems, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | Sozeri-Varma G, Kalkan-Oguzhanoglu N, Efe M, et al. Neurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression. Neuropsychiatr Dis Treat 2013;9:1053-9. |
Metabolite |
