Study M306
Study name | Liu WB 2013 |
Title | [Correlation of neurochemical metabolism with memory function in young adult patients with first-episode depression studied with proton magnetic resonance spectroscopy] |
Overall design | The aim of this study was to investigate the correlation of neurochemical metabolism in hippocampus with memory function in young adult patients with first-episode depression. Patients with first-episode depression (depression group, n = 20) and health subjects (control group, n = 15) were enrolled in the study. The neurochemical metabolism, including the levels of N-acetylaspartate (NAA), Choline (Cho), Creatine (Cr), Myoinositol (mI) were measured by proton magnetic resonance spectroscope (1H-MRS) in bilateral hippocampus. Wechsler Memory Scale (WMS) were used to examine the memory function in both groups. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | ICD-10 diagnosed MDD, HAMD-17 > 17 |
Sample size | 35 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 3.0 Tesla MR scanner (GE, USA); |
PMID | |
DOI | |
Citation | Liu W, Yu H, Jiang B, et al. [Correlation of neurochemical metabolism with memory function in young adult patients with first-episode depression studied with proton magnetic resonance spectroscopy]. Zhejiang Da Xue Xue Bao Yi Xue Ban 2013;42(4):450-5. (Article in Chinese) |
Metabolite |
