Study M305
Study name | de Diego-Adelino J 2013 |
Title | Hippocampal abnormalities of glutamate/glutamine, N-acetylaspartate and choline in patients with depression are related to past illness burden |
Overall design | The aim of this study was to investigate metabolite abnormalities in the hippocampus associated with past depressive illness burden. Glutamate/glutamine (Glx), N-acetylaspartate (NAA) and choline (Cho), potential markers of glial/neuronal integrity and membrane turnover, respectively, were measured in adults with depression (n = 21) and healthy controls (control group, n = 21) using a 3 T magnetic resonance spectroscopy scanner. Patients were divided into three groups, including first-episode MDD (first-episode depression group, n = 14), remitted-recurrent MDD (remitted depression group, HAMD < 8, n = 18) and chronic MDD (chronic depression group, n = 20). Voxels were placed in the head of the right and left hippocampus. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD |
Sample size | 68 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 3 T Philips Achieva scanner; |
PMID | |
DOI | |
Citation | de Diego-Adelino J, Portella MJ, Gómez-Anson B, et al. Hippocampal abnormalities of glutamate/glutamine, N-acetylaspartate and choline in patients with depression are related to past illness burden. J Psychiatry Neurosci 2013;38(2):107-16. |
Metabolite |
