Study M304
Study name | Shungu DC 2012 |
Title | Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology |
Overall design | In this independent cross-sectional neuroimaging study, we investigated a pathophysiological model which postulated that elevations of cerebrospinal fluid (CSF) lactate in patients with chronic fatigue syndrome (CFS) might be caused by increased oxidative stress, cerebral hypoperfusion and/or secondary mitochondrial dysfunction. Fifteen patients with CFS, 15 with major depressive disorder (depression group) and 13 healthy volunteers (control group) were studied using the following modalities: (i) 1H MRSI to measure CSF lactate; (ii) single-voxel 1H MRS to measure levels of cortical glutathione (GSH) as a marker of antioxidant capacity; (iii) arterial spin labeling (ASL) MRI to measure regional cerebral blood flow; and (iv) 31P MRSI to measure brain high-energy phosphates as objective indices of mitochondrial dysfunction. Ventricular lactate was reported in institutional units. Glutathione levels normalized to the peak area of the unsuppressed voxel tissue water. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 28 |
Tissue | Central; Cerebrospinal fluid; Cerebrospinal fluid; Central; Brain; Occipital lobe; |
Platform | MRS; MRS: General Electric 3.0-T EXCITE MR system; |
PMID | |
DOI | |
Citation | Shungu DC, Weiduschat N, Murrough JW, et al. Increased ventricular lactate in chronic fatigue syndrome. III. Relationships to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathophysiology. NMR Biomed 2012;25(9):1073-87. |
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