Study M302

Study name

Chen SQ 2012

Title

Imaging changes in neural circuits in patients with depression using (1)H-magnetic resonance spectroscopy and diffusion tensor imaging

Overall design

The aims of this study were to explore whether the microstructural and metabolic changes occur consistently in specific brain regions within the neural circuit in patients with mild depression; and to examine for correlations between detected microstructural changes, metabolic changes, and the Hamilton depression score. 1H-magnetic resonance spectroscopy imaging and diffusion tensor imaging were performed in patients with mild depression (depression group, n = 19) and in controls (control group, n = 13). N-acetylaspartate, choline and creatine concentrations and the average diffusion coefficient and fractional anisotropy values were measured in the bilateral hippocampus, striatum, thalamus and prefrontal deep white matter. Metabolite quantification was reported relative to total creatine as the reference peak.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

ICD-10 diagnosed MDD, CCMD-3 diagnosed MDD

Sample size

32

Tissue

Central; Brain; Prefrontal deep white matter;

Central; Brain; Striatum;

Central; Brain; Thalamus;

Central; Brain; Hippocampus;

Platform

MRS; MRS: 1.5 T MRI scanner (Signa Excite II; GE Healthcare, Bethesda, MD, USA);

PMID

25624814

DOI

10.3969/j.issn.1673-5374.2012.24.006

Citation

Chen S, Lai L, Kang Z, et al. Imaging changes in neural circuits in patients with depression using (1)H-magnetic resonance spectroscopy and diffusion tensor imaging. Neural Regen Res 2012;7(24):1881-8.

Metabolite

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;