Study M301

Study name

Wang Y 2012b

Title

Frontal white matter biochemical abnormalities in first-episode, treatment-naive patients with major depressive disorder: a proton magnetic resonance spectroscopy study

Overall design

This study sought to explore the brain biochemical changes of first-episode, treatment-naive, non-late-life adult patients with major depressive disorder (MDD) in the frontal white matter and gray matter by using proton magnetic resonance spectroscopy (1H MRS). First-episode, treatment-naive, non-late-life adult depressed patients (depression group, n = 24) and healthy controls (control group, n = 13) were enrolled in this study. Subjects underwent two-dimensional multivoxel 1H MRS at 1.5 T to obtain bilateral metabolite levels from the dorsolateral prefrontal white matter and anterior cingulate gray matter. Metabolite quantification was reported relative to total creatine as the reference peak.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD, HAMD-17 >= 18

Sample size

37

Tissue

Central; Brain; Dorsolateral prefrontal white matter;

Central; Brain; Anterior cingulate gray matter;

Platform

MRS; MRS: 1.5 T GE Signa MR system (General Electric, Milwaukee, WI, USA);

PMID

22129769

DOI

10.1016/j.jad.2011.10.020

Citation

Wang Y, Jia Y, Xu G, et al. Frontal white matter biochemical abnormalities in first-episode, treatment-naive patients with major depressive disorder: a proton magnetic resonance spectroscopy study. J Affect Disord 2012;136(3):620-6.

Metabolite

N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio;

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;