Study M300
Study name | Wang Y 2012a |
Title | Hippocampal N-acetylaspartate and morning cortisol levels in drug-naive, first-episode patients with major depressive disorder: effects of treatment |
Overall design | In the present study, metabolic characteristics in the bilateral hippocampus of first-episode, treatment-naive, non-late-life adult patients with major depressive disorder (MDD) and healthy controls were investigated with proton magnetic resonance spectroscopy (1H MRS). The interrelationships between hippocampal metabolites and cortisol levels were evaluated specifically. For this study, first-episode, treatment-naive, non-late-life adult depressed patients (depression group, n = 26) and healthy controls (control group, n = 13) were enrolled. Subjects underwent 1H MRS to obtain metabolite levels from the bilateral hippocampus. Patients with MDD were treated with duloxetine (60-120 mg/day) for 12 weeks. After the 12-week period, all subjects with MDD underwent 1H MRS again. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 18 |
Sample size | 39 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 1.5 Tesla GE Signa MR system (General Electric, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | Wang Y, Jia Y, Chen X, et al. Hippocampal N-acetylaspartate and morning cortisol levels in drug-naive, first-episode patients with major depressive disorder: effects of treatment. J Psychopharmacol 2012;26(11):1463-70. |
Metabolite |
