Study M299
Study name | Wang X 2012 |
Title | Glutamate level detection by magnetic resonance spectroscopy in patients with post-stroke depression |
Overall design | The objectives of this study were to detect metabolic changes in the cingulate cortex after cerebral infarction and to clarify whether the metabolic changes can predict the occurrence of depression after cerebral infarction. Healthy volunteers (control group, n = 15) and a group of 51 patients who experienced stroke for the first time and had a good prognosis were enrolled. The patients with infarction were divided into three groups according to their scores by using the DSM-IV diagnostic criteria for major depressive disorder and the 17-item Hamilton Depression Rating Scale (HDRS), including: (1) stroke patients with no depression and an HDRS score < 14 points (stroke without depression group, n = 31), (2) stroke patients with normal mood but an HDRS score >= 14 (stroke with depression symptom group, n = 9), and (3) stroke patients diagnosed with depression, having an HDRS score >= 14 (stroke with depression disorder group, n = 11). Single-voxel proton magnetic resonance spectroscopy (1H-MRS) was performed to assess N-acetylaspartate/creatine (NAA)/Cr, glutamate (Glu)/Cr, choline (Cho)/Cr, and myoinositol (mI)/Cr ratios in stroke patients. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Post-stroke depression; Post-stroke depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 14 |
Sample size | 66 |
Tissue | Central; Brain; Frontal lobe; |
Platform | MRS; MRS: Philips 3 T MRI system (Achieva); |
PMID | |
DOI | |
Citation | Wang X, Li YH, Li MH, et al. Glutamate level detection by magnetic resonance spectroscopy in patients with post-stroke depression. Eur Arch Psychiatry Clin Neurosci 2012;262(1):33-8. |
Metabolite |
