Study M298
Study name | Taylor MJ 2012a |
Title | Early increase in marker of neuronal integrity with antidepressant treatment of major depression: 1H-magnetic resonance spectroscopy of N-acetyl-aspartate |
Overall design | This study used magnetic resonance spectroscopy to assess effects of short-term treatment with escitalopram on N-acetyl-aspartate (NAA), a marker of neuronal integrity. Thirty-nine participants with major depression were randomly assigned to receive either 10 mg escitalopram (escitalopram group, n = 19) or placebo (placebo group, n = 21) daily in a double-blind, parallel group design. On the seventh day of treatment, PRESS data were obtained from a 30x30x20 mm voxel placed in medial frontal cortex. Age and gender-matched healthy controls (control group, n = 27) who received no treatment were also scanned. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 66 |
Tissue | Central; Brain; Medial frontal cortex; |
Platform | MRS; MRS: 3 T Siemens Trio (Erlangen, Germany) system; |
PMID | |
DOI | |
Citation | Taylor MJ, Godlewska BR, Norbury R, et al. Early increase in marker of neuronal integrity with antidepressant treatment of major depression: 1H-magnetic resonance spectroscopy of N-acetyl-aspartate. Int J Neuropsychopharmacol 2012;15(10):1541-6. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; (N-Acetyl aspartate and N-Acetylglutamic acid)/(Creatine and Phosphocreatine) ratio; |
