Study M296
Study name | Menke A 2012 |
Title | Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypes |
Overall design | The aim of this study was to test whether these findings can also be supported by human genetics data, the authors explored polymorphisms within the metabotropic glutamate receptor 1 gene (GRM1) for their association with unipolar depression (UPD) as well as with biological phenotypes of this disorder. 1H-MR-spectra of the left hippocampus were obtained from a total of 198 subjects of the second sample, comprising 104 patients (depression group) and 94 control subjects (control group). Differences of glutamate (Glu) and unresolved glutamate and glutamine resonances (Glx) between currently patients (currently depressed group, BDI > 14, n = 26), currently non-depressed patients (n = 36) and controls (control group, n = 50) were compared. Metabolite quantification was reported in institutional units. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV or ICD-10 diagnosed MDD, BDI > 14 |
Sample size | 112 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 1.5 T MR; |
PMID | |
DOI | |
Citation | Menke A, Samann P, Kloiber S, et al. Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypes. Psychoneuroendocrinology 2012;37(4):565-75. |
Metabolite |
