Study M294
Study name | Hemanth Kumar BS 2012 |
Title | Neurodegenerative evidences during early onset of depression in CMS rats as detected by proton magnetic resonance spectroscopy at 7 T |
Overall design | The aim of this study was to investigate the neurometabolite changes occurring in prefrontal cortex and hippocampus during the onset of depression, in chronic mild stress (CMS) rat model using in vivo proton magnetic resonance spectroscopy (1H MRS) at field strength of 7 T. Rats were divided into the following 2 groups (n = 10 in each group): (1) control group, (2) CMS group. The CUMS stress procedure lasted for 6 weeks. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 20 |
Tissue | Central; Brain; Hippocampus; Central; Brain; Prefrontal cortex; |
Platform | MRS; MRS: 7 T Bruker Biospec USR 70/30, (AVANCE III); |
PMID | |
DOI | |
Citation | Hemanth Kumar BS, Mishra SK, Rana P, et al. Neurodegenerative evidences during early onset of depression in CMS rats as detected by proton magnetic resonance spectroscopy at 7 T. Behav Brain Res 2012;232(1):53-9. |
Metabolite | myo-Inositol/(Creatine and Phosphocreatine) ratio; GABA/(Creatine and Phosphocreatine) ratio; (Glutamate and Glutamine)/(Creatine and Phosphocreatine) ratio; Glutamine/(Creatine and Phosphocreatine) ratio; Glutamate/(Creatine and Phosphocreatine) ratio; Taurine/(Creatine and Phosphocreatine) ratio; (N-Acetyl aspartate and N-Acetylglutamic acid)/(Creatine and Phosphocreatine) ratio; |
