Study M293
Study name | Grimm S 2012 |
Title | Region-specific glutamate changes in patients with unipolar depression |
Overall design | The present study aimed to investigate glutamate concentrations in patients with unipolar depression in the midcingulate cortex (MCC) as compared to the left dorsolateral prefrontal cortex (DLPFC). Glutamate was determined using magnetic resonance spectroscopy at 3 T in DLPFC and MCC in depressed patients (depression group, n = 14) and matched healthy volunteers (control group, n = 14). A follow-up measurement was performed after 4 weeks of antidepressant treatment. Response to antidepressant therapy was defined as a 50% reduction in the Hamilton Depression Rating Scale scores (HDRS) 17-item version. Clinical response to antidepressant treatment was fulfilled in 7 patients (responder group), and not fulfilled in another 7 patients (non-responder group). Metabolite quantification was normalized to phantom. |
Study Type | Type1; Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 28 |
Tissue | Central; Brain; Midcingulate cortex; Central; Brain; Dorsolateral prefrontal cortex; |
Platform | MRS; MRS: 3 T scanner (MEDSPEC 30/100, Bruker Biospin, Ettlingen, Germany); |
PMID | |
DOI | |
Citation | Grimm S, Luborzewski A, Schubert F, et al. Region-specific glutamate changes in patients with unipolar depression. J Psychiatr Res 2012;46(8):1059-65. |
Metabolite |
