Study M291
Study name | Merkl A 2011 |
Title | Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy |
Overall design | The aim of this study was to determine the concentrations of N-acetyl-aspartate (NAA), choline-containing compounds, creatine + phosphocreatine (tCr), and glutamate in the left dorsolateral prefrontal cortex (DLPFC) and left anterior cingulum of depressed patients before and after electroconvulsive therapy (ECT), we used proton magnetic resonance spectroscopy. Metabolite concentrations in the DLPFC and anterior cingulum were determined in patients with major depressive disorder (depression group, n = 25) and healthy control subjects (control group, n = 27) using the point resolved spectroscopy sequence. Neuropsychological and clinical parameters were determined before and after nine sessions of right unilateral ultrabrief pulse ECT. Response to antidepressant therapy was defined as a 50% reduction in the Hamilton Depression Rating Scale (HDRS) 17-item version. The ECT associated response (responder group, n = 17) versus non-response (non-responder group, n = 8) groups were compared for metabolic changes after treatment. Metabolite concentrations were corrected for the cerebrospinal fluid in the voxels studied by using the cerebrospinal fluid fractions. |
Study Type | Type1; Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 52 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; Central; Brain; Anterior cingulate; |
Platform | MRS; MRS: 3-Tesla scanner (MEDSPEC 30/100, Bruker Biospin, Ettlingen, Germany); |
PMID | |
DOI | |
Citation | Merkl A, Schubert F, Quante A, et al. Abnormal cingulate and prefrontal cortical neurochemistry in major depression after electroconvulsive therapy. Biol Psychiatry 2011;69(8):772-9. |
Metabolite |
