Study M290
Study name | Delgado y Palacios R 2011 |
Title | Magnetic resonance imaging and spectroscopy reveal differential hippocampal changes in anhedonic and resilient subtypes of the chronic mild stress rat model |
Overall design | The aim of this study was to examine the morphological, microstructural, and metabolic characteristics of the hippocampus in anhedonic and stress resilient rats that may mark the differential behavioral outcome. Rats were divided into the following 2 groups: (1) control group, (2) CMS group. The CMS stress procedure lasted for 8 weeks. Based on sucrose intake at the end of the stress protocol, the challenged group was subdivided into CMS sensitive or anhedonic and CMS resilient animals. Two such subgroups were assigned for the reported MRI study together with an unchallenged control group (control group, n = 8; anhedonic group, n = 8; resilient group, n = 8). Rats were subjected to in vivo diffusion kurtosis imaging, high-resolution three-dimensional magnetic resonance imaging and proton magnetic resonance spectroscopy. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Wistar rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 24 |
Tissue | Central; Brain; Ventral hippocampus; |
Platform | MRS; MRS: 9.4 T Bruker Biospec system (Biospec 94/20 Ultra-Shielded and Refrigerated, Bruker Biospin, Ettlingen, Germany); |
PMID | |
DOI | |
Citation | Delgado y Palacios R, Campo A, Henningsen K, et al. Magnetic resonance imaging and spectroscopy reveal differential hippocampal changes in anhedonic and resilient subtypes of the chronic mild stress rat model. Biol Psychiatry 2011;70(5):449-57. |
Metabolite | Creatine and Phosphocreatine; |
