Study M289
Study name | Yuan H 2011 |
Title | [Magnetic resonance spectroscopy observation on brain metabolic changes in patients with depression] |
Overall design | The aim of this study was to assess the correlation between abnormal metabolic changes and Wisconsin card sorted test (WCST) in patients with depression using magnetic resonance spectroscopy (MRS). Healthy volunteers (control group, n = 12), first-episode patients (first-episode depression group, n = 12) and recurrent patients (recurrent depression group, n = 10) underwent WCST before MR examination. Localized magnetic resonance spectra were acquired in bilateral prefrontal lobe and cingulated cortex with single voxel 1-hydrogen MRS (1H-MRS). The ratio of all metabolte including N-acetyl-asparta (NAA), choline (Cho), glutamate and glutamine (Glx) were recorded, using creatine (Cr) as reference. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | CCMD-3 diagnosed MDD, HAMD-17 >= 24 |
Sample size | 34 |
Tissue | Central; Brain; Prefrontal cortex; Central; Brain; Cingulate cortex; |
Platform | MRS; MRS: Philips Marconi Eclipse 1.5 T Superconductive Imaging System; |
PMID | |
DOI | |
Citation | Yuan H, Qi J. [Magnetic resonance spectroscopy observation on brain metabolic changes in patients with depression]. Chinese Journal of Medical Imaging Technology 2011;27(2):286-90. (Article in Chinese) |
Metabolite | myo-Inositol/(Creatine and Phosphocreatine) ratio; (Glutamate and Glutamine)/(Creatine and Phosphocreatine) ratio; |
