Study M288
Study name | Xi GJ 2011 |
Title | Learning and memory alterations are associated with hippocampal N-acetylaspartate in a rat model of depression as measured by 1H-MRS |
Overall design | The present study used a rat model of depression, chronic unpredictable mild stress (CUMS), to determine whether hippocampal volume and neurochemical changes were involved in learning and memory alterations. A further aim was to determine whether these effects could be ameliorated by escitalopram treatment, as assessed with the non-invasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Rats were divided into the following 4 groups (n = 6 in each group): (1) control group, (2) CUMS group, (3) escitalopram group (escitalopram treatment at the dose of 10 mg/kg), (4) CUMS + escitalopram group (stressor plus escitalopram treatment at the dose of 10 mg/kg). The CUMS stress procedure lasted for 6 weeks, and escitalopram was administered i.p. once per day during last 4 weeks of the model building period. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Healthy individuals; Healthy individuals; Healthy individuals; Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 24 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 7.0 T animal MRI scanner (70/16 PharmaScan, Bruker Biospin GmbH, Germany); |
PMID | |
DOI | |
Citation | Xi G, Hui J, Zhang Z, et al. Learning and memory alterations are associated with hippocampal N-acetylaspartate in a rat model of depression as measured by 1H-MRS. PLoS One 2011;6(12):e28686. |
Metabolite |
