Study M287
Study name | Portella MJ 2011 |
Title | Ventromedial prefrontal spectroscopic abnormalities over the course of depression: a comparison among first episode, remitted recurrent and chronic patients |
Overall design | The aim of this study was to investigate whether glutamate (Glu), choline (Cho) and total N-acetylaspartate (total-NAA) levels in the ventromedial prefrontal cortex (vmPFC) differed among major depression (MDD) patients in distinct stages of illness and healthy controls. A 3-Tesla MR facility was used to measure these metabolites in vmPFC of 45 depressive patients, including first-episode MDD (first-episode depression group, n = 10), remitted-recurrent MDD (remitted depression group, n = 16) and chronic MDD (chronic depression group, n = 19), and healthy controls (control group, n = 15). Multivariate and correlation analyses were carried out to explore the influence of duration of illness, age at onset and mood-state. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD |
Sample size | 60 |
Tissue | Central; Brain; Ventromedial prefrontal cortex; |
Platform | MRS; MRS: 3 T Philips Achieva facility; |
PMID | |
DOI | |
Citation | Portella MJ, de Diego-Adelino J, Gomez-Anson B, et al. Ventromedial prefrontal spectroscopic abnormalities over the course of depression: a comparison among first episode, remitted recurrent and chronic patients. J Psychiatr Res 2011;45(4):427-34. |
Metabolite |
