Study M285
Study name | Jarnum H 2011 |
Title | Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder |
Overall design | The aim of this study was to determine whether patients with major depressive disorder (MDD) display morphologic, functional, and metabolic brain abnormalities in limbic-cortical regions at a baseline magnetic resonance (MR) scan and whether these changes are normalized in MDD patients in remission at a follow-up scan. A longitudinal 3.0-Tesla magnetic resonance imaging (MRI) study was carried out with cortical thickness measurements with a surface-based approach, perfusion measurements with three-dimensional pseudo-continuous arterial spin labeling, and spectroscopy (1H-MRS) measurements in the anterior cingulate cortex (ACC) with water as an internal reference adjusted for cerebrospinal fluid content. MDD patients (depression group, n = 23) and healthy controls (control group, n = 26) were examined. MDD patients underwent a baseline MRI at inclusion and were invited to a follow-up scan when they were in remission or after a 6-month follow-up period. Metabolite quantification was reported in arbitrary units. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | ICD-10 diagnosed MDD, HAMD-17 >= 18 |
Sample size | 49 |
Tissue | Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: 3-T whole-body MRI system (Signa HDx, R14M5, GE Healthcare); |
PMID | |
DOI | |
Citation | Järnum H, Eskildsen SF, Steffensen EG, et al. Longitudinal MRI study of cortical thickness, perfusion, and metabolite levels in major depressive disorder. Acta Psychiatr Scand 2011;124(6):435-46. |
Metabolite |
