Study M284
Study name | Hui JJ 2011 |
Title | Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: a magnetic resonance study |
Overall design | The aim of this study was to investigate whether hippocampus volume and neurochemical changes were involved in the appearance of these effects in the maternal separation (MS) animal model using the noninvasive techniques of structural magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). Sprague-Dawley rats exposed to MS for 180 min from postnatal days (PND) 2-14 demonstrated decreased sucrose preference, increased immobility in the forced swimming test (FST), and impaired memory in the Morris water maze in adulthood. Fifty rats were divided into the following 4 groups (n = 12-13 in each group): (1) control group (no maternal separation stress, standard housing condition), (2) MS group (maternal separation stress, standard housing condition), (3) EE group (no maternal separation stress, and environmental enrichment housing condition), (4) MS + EE group (maternal separation stress plus environmental enrichment housing condition). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; Type3; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Other animal model; Other animal model; Healthy individuals; Healthy individuals; Healthy individuals; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 50 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 7.0 T animal MRI scanner (70/16 PharmaScan, Bruker Biospin GmbH, Germany); |
PMID | |
DOI | |
Citation | Hui JJ, Zhang ZJ, Liu SS, et al. Hippocampal neurochemistry is involved in the behavioural effects of neonatal maternal separation and their reversal by post-weaning environmental enrichment: a magnetic resonance study. Behav Brain Res 2011;217(1):122-7. |
Metabolite |
