Study M281

Study name

Herman-Sucharska I 2010

Title

[Usefulness of proton MR spectroscopy for determining diagnosis and treatment outcome in unipolar depressive disorder]

Overall design

The aim of the study was to evaluate the usefulness of proton MR spectroscopy for determining the biochemical abnormalities in acute episode of depression and after regression of the disease in course of unipolar depressive disorder. Patients (depression group, n = 41) with known unipolar depressive disorder (a Hamilton Depression Rating Scale of 16 or greater) were evaluated by the means of HMRS during acute episode of depression and after positive therapeutic response (at least 50% reduced Hamilton score for at least 4 consecutive weeks). Age-matched healthy controls (control group, n = 40) were also recruited. All patients underwent single-volume 1H MRS (TR = 1500 ms, TE = 35 ms) using a 1.5 T scanner. Four brain areas were analyzed: both frontal lobes and both hippocampi. Metabolite quantification was reported relative to total creatine as the reference peak.

Study Type

Type1;

Type2;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

ICD-10 diagnosed MDD, HAMD-17 >= 16

Sample size

81

Tissue

Central; Brain; Frontal lobe;

Central; Brain; Hippocampus;

Platform

MRS; MRS: MR Signa Excite 1.5 T system (General Electric);

PMID

20687353

DOI

N/A

Citation

Herman-Sucharska I, Werewka-Maczuga A, Urbanik A, et al. [Usefulness of proton MR spectroscopy for determining diagnosis and treatment outcome in unipolar depressive disorder]. Przegl Lek 2010;67(4):243-6. (Article in Polish)

Metabolite

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;

myo-Inositol/(Creatine and Phosphocreatine) ratio;