Study M280
Study name | Rao V 2010 |
Title | Neuroanatomical correlates of depression in post traumatic brain injury: preliminary results of a pilot study |
Overall design | The aim of this study was to examine cognitive and neuroanatomical correlates of post- post traumatic brain injury (TBI) depression using proton magnetic resonance spectroscopy imaging (MRSI) and volumetric MRI, comparing TBI patients with and without depression. Brain metabolite ratios, regional brain volumes, and cognitive performance were compared between subjects with incident major depression post-TBI (TBI with depression group, n = 10) and TBI patients without major depression (TBI without depression group, n = 7). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression with comorbidity; Depression with comorbidity; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 17 |
Tissue | Central; Brain; Frontal lobe; Central; Brain; Occipital lobe; Central; Brain; Temporal lobe; Central; Brain; Basal ganglia; |
Platform | MRS; MRS: not reported; |
PMID | |
DOI | |
Citation | Rao V, Munro CA, Rosenberg P, et al. Neuroanatomical correlates of depression in post traumatic brain injury: preliminary results of a pilot study. J Neuropsychiatry Clin Neurosci 2010;22(2):231-5. |
Metabolite | Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
