Study M279
Study name | Zheng HR 2010 |
Title | High-frequency rTMS treatment increases left prefrontal myo-inositol in young patients with treatment-resistant depression |
Overall design | In this study, metabolic changes within prefrontal cortex (PFC) of severely depressed patients before and after repetitive transcranial magnetic stimulation (rTMS) were evaluated by proton magnetic resonance spectroscopy (1H-MRS). Young depressed patients with treatment-resistant unipolar depression (depression group, n = 34) were enrolled in a double-blind, randomized study active (rTMS group, n=19; sham rTMS group, n=15), and the PFC was investigated before and after high-frequency (15 Hz) rTMS using 3-tesla proton magnetic resonance spectroscopy. Treatment resistance was defined as failure to respond to at least two different antidepressants given for a period longer than 4 weeks at the maximum recommended dose. All patients were taking escitalopram 10 mg per day for at least 2 weeks before their enrollment, and they agreed to not change medication during the study. Response was defined as a 50% reduction of the Hamilton depression rating scale. The results were compared with age- and gender-matched healthy controls (control group, n = 28). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 24 |
Sample size | 62 |
Tissue | Central; Brain; Prefrontal cortex; |
Platform | MRS; MRS: 3.0 Tesla Siemens whole body imaging system (Trio Tim, Siemens, Germany); |
PMID | |
DOI | |
Citation | Zheng H, Zhang L, Li L, et al. High-frequency rTMS treatment increases left prefrontal myo-inositol in young patients with treatment-resistant depression. Prog Neuropsychopharmacol Biol Psychiatry 2010;34(7):1189-95. |
Metabolite |
