Study M278
Study name | Olvera RL 2010 |
Title | Reduced medial prefrontal N-acetyl-aspartate levels in pediatric major depressive disorder: a multi-voxel in vivo (1)H spectroscopy study |
Overall design | The aim of this study was to examine whether similar abnormalities occur in children and adolescents with major depressive disorder (MDD). Children and adolescents aged 8-17 years with MDD (depression group, n = 16) and healthy control subjects (control group, n = 38) were recruited. Two-dimensional multi-voxel in vivo 1H spectroscopy data was collected at 1.5 Tesla to quantify levels of N-acetyl-aspartate (NAA), glycerolphosphocholine plus phosphocholine (GPC + PC), and phosphocreatine plus creatine (PCr + Cr) in the dorsolateral prefrontal cortex (DLPFC), medial prefrontal cortex (MPFC), and anterior cingulate (AC). Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Pediatric depression; Pediatric depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 54 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; Central; Brain; Medial prefrontal cortex; Central; Brain; Anterior cingulate; |
Platform | MRS; MRS: 1.5 Tesla MR; |
PMID | |
DOI | |
Citation | Olvera RL, Caetano SC, Stanley JA, et al. Reduced medial prefrontal N-acetyl-aspartate levels in pediatric major depressive disorder: a multi-voxel in vivo (1)H spectroscopy study. Psychiatry Res 2010;184(2):71-6. |
Metabolite |
