Study M275
Study name | Huang YY 2010 |
Title | Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: a study using 1H magnetic resonance spectroscopy |
Overall design | The aim of this study was to determine the biochemical abnormalities that occur in post-stroke depression (PSD) and to assess the effect of antidepressants in patients with PSD at the biochemical level. We used magnetic resonance imaging to detect structural or functional abnormalities in PSD patients. Patients with PSD (depression group, n = 30) and age-matched subjects (control group, n = 20) were enrolled. Magnetic resonance spectroscopy (MRS) of the brain was conducted in all subjects at the beginning of the study. Patients with PSD were treated with the antidepressant paroxetine (20-40 mg/days) for 6 months. After the 6-month period, all PSD subjects underwent MRS again. PSD patients were evaluated with the Hamilton Depression Scale (HAMD) both before and after treatment with the antidepressant. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Post-stroke depression; Post-stroke depression; Depressive disorder; Geriatric depression; Geriatric depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 50 |
Tissue | Central; Brain; Thalamus; Central; Brain; Hippocampus; |
Platform | MRS; MRS: 3.0 T GE Signa Highspeed Superconductive Imaging System (GE Medical Systems, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | Huang Y, Chen W, Li Y, et al. Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: a study using 1H magnetic resonance spectroscopy. Psychiatry Res 2010;182(1):48-52. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
