Study M273
Study name | Duan DM 2010 |
Title | Combined effects of electroacupuncture and anti-depression drugs on the hippocampus and frontal lobe |
Overall design | In the present study, the clinical outcomes of 75 depression patients, who were treated with electroacupuncture (EA) and fluoxetine, were observed. Bilateral hippocampal volumes, as well as ratios of N-acetylaspartate (NAA), choline (Cho), and creatine (Cr), before and after anti-depression treatment, were quantitatively analyzed using magnetic resonance imaging (MRI) and 1H-MRS. A total of 75 patients undergoing treatment for depression were initially included. Five patients withdrew from treatment; thus 70 patients were included in the final analysis, comprising 34 patients receiving oral fluoxetine (fluoxetine group) and 36 receiving EA in combination with fluoxetine (EA + fluoxetine group). The fluoxetine group patients were treated with the fluoxetine orally at a dose of 20 mg/d for 6 consecutive weeks. In the EA + fluoxetine group, patients were treated with both fluoxetine for 6 weeks and electroacupuncture for six treatment courses. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | ICD-10 diagnosed MDD, HAMD-17 > 20 and < 35 |
Sample size | 70 |
Tissue | Central; Brain; Frontal lobe; Central; Brain; Hippocampus; |
Platform | MRS; MRS: GE Excite II Signa 3.0 T MRI system (GE, Fairfield, Connecticut, USA); |
PMID | |
DOI | |
Citation | Duan DM, Tu Y, Jiao S, et al. Combined effects of electroacupuncture and anti-depression drugs on the hippocampus and frontal lobe. Neural Regen Res 2010; 5(22):1723-7. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
