Study M272
Study name | Walter M 2009 |
Title | The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression |
Overall design | The aim of this study was to contextualize metabolic, functional, and clinical parameters and thus to reveal cellular mechanisms related to anhedonia. The pregenual anterior cingulate cortex (pgACC) was investigated using a combined functional magnetic resonance imaging and magnetic resonance spectroscopic approach. Negative blood oxygenation level-dependent (BOLD) activations in the pgACC were assessed during emotional stimulation. Quantitative J-resolved magnetic resonance spectroscopy in the pgACC enabled simultaneous determination of glutamine, glutamate, N-acetylaspartate, glucose, and gamma-aminobutyric acid concentrations. Subjective emotional intensity ratings as well as various clinical parameters were determined. Unmedicated patients with MDD (depression group, n = 19) and healthy subjects (control group, n = 24) were recruited. Based on patients' mean anhedonia scores, patients were divided into subgroups, including (1) major depressive disorder with anhedonia scores higher than the mean group (MDDhA group), and (2) major depressive disorder with anhedonia scores lower than the mean group (MDDlA group). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | Acute MDD episode, HAMD-21 >= 24, BDI-21 >= 24 |
Sample size | 43 |
Tissue | Central; Brain; Pregenual anterior cingulate cortex; |
Platform | MRS; MRS: Philips Intera 3 T whole-body magnetic resonance unit (Philips Healthcare, Best, the Netherlands); |
PMID | |
DOI | |
Citation | Walter M, Henning A, Grimm S, et al. The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression. Arch Gen Psychiatry 2009;66(5):478-86. |
Metabolite |
