Study M271
Study name | Yang R 2009 |
Title | [Proton magnetic resonance spectroscopy of the thalamus and hypothalamus in patients with first-episode depression] |
Overall design | The aim of this study was to investigate the presence of abnormal metabolism in the thalamus and hypothalamus in patients with first-episode depression. Drug-naive patients with first-episode depression (depression group, n = 30) and age-matched controls (control group, n = 30) were scanned with proton magnetic resonance spectroscopy (1H-MRS) for N-acetyl-aspartate (NAA), choline-containing compounds (Cho), creatine and phosphocreatine (Cr), and myo-inositol (mI). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 17 |
Sample size | 60 |
Tissue | Central; Brain; Thalamus; Central; Brain; Hypothalamus; |
Platform | MRS; MRS: GE 1.5 T Signa Excite 11.0 Superconductive Imaging System (General Electric Medical Systems); |
PMID | |
DOI | |
Citation | Yang R, Wu XP, Bai XY, et al. [Proton magnetic resonance spectroscopy of the thalamus and hypothalamus in patients with first-episode depression]. Nan Fang Yi Ke Da Xue Xue Bao 2009;29(12):2442-5. (Article in Chinese) |
Metabolite |
