Study M268
Study name | Li J 2009 |
Title | [A proton magnetic spectroscopy research on hippocampus metabolisms in people with suicide-attempted depressions] |
Overall design | The aim of this study was to investigate the metabolic features of hippocampus in people with suicide-attempted depressions. Proton resonance spectroscopy (1H-MRS) was performed on the bilateral hippocampi of patients with suicide-attempted depressions (depression group, n = 24) and healthy people (control group, n = 24). The ratios of N-acetylasparte (NAA)/creatine (Cr), choline (Cho)/Cr and myoinositol (mI)/Cr were calculated and used as markers reflecting the metabolic levels of NAA, Cho and mI. The differences between the patients with suicide-attempted depressions and the healthy people were analyzed. The left hippocampus was also compared with the right to determine the asymmetry of the hippocampus metabolic. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression with suicide; Depression with suicide; |
Criteria for depression | CCMD-3 diagnosed MDD |
Sample size | 48 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 3.0 T MR system (GE Medical Systems, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | Li J, Kuang WH, Zou K, et al. [A proton magnetic spectroscopy research on hippocampus metabolisms in people with suicide-attempted depressions]. Sichuan Da Xue Xue Bao Yi Xue Ban 2009;40(1):59-62. (Article in Chinese) |
Metabolite |
