Study M267
Study name | Kaymak SU 2009 |
Title | Antidepressant effect detected on proton magnetic resonance spectroscopy in drug-naive female patients with first-episode major depression |
Overall design | The aim of the present study was to examine the biochemical characteristics of left dorsolateral prefrontal cortex (DLPFC), as measured on proton (1H magnetic resonance spectroscopy (MRS) in patients with drug-naive first-episode MDD and a healthy control group. A second aim was to assess the effect of antidepressant treatment on the metabolites of DLPFC. Short-echo single-voxel 1H-MRS was done for the left DLPFC in female drug-free MDD patients (depression group, n = 17) and matched control subjects (control group, n = 13) and was repeated at 8 weeks following SSRIs treatment. The medications that the patients were using after inclusion in the study and number of patients using that medication were as follows: 50 mg/day sertraline (n = 5), 10 mg/day escitalopram (n = 5), 20 mg/day paroxetine (n = 5), and 20 mg/day fluoxetine (n = 2). Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 17 |
Sample size | 30 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; |
Platform | MRS; MRS: 3.0 T scanner (Allegra, VA25, Siemens, Erlangen, Germany); |
PMID | |
DOI | |
Citation | Kaymak SU, Demir B, Oguz KK, et al. Antidepressant effect detected on proton magnetic resonance spectroscopy in drug-naive female patients with first-episode major depression. Psychiatry Clin Neurosci 2009;63(3):350-6. |
Metabolite |
