Study M266
Study name | Forester BP 2009 |
Title | 31Phosphorus magnetic resonance spectroscopy study of tissue specific changes in high energy phosphates before and after sertraline treatment of geriatric depression |
Overall design | The aim of this study was to investigate tissue specific differences in markers of energy metabolism, including high energy phosphate compounds (beta and total NTP, PCr) and pH, in older adults with depression compared with healthy controls, before and after a 12-week treatment trial of sertraline. The dose of sertraline was adjusted as clinically indicated by 25 mg or 50 mg increments up to a maximum of 200 mg per day. Thirteen older adults, age > or = 55, with Major Depressive Disorder (depression group, n = 13) were recruited along with age-matched controls(control group, n = 10). The depression subjects had a pre- and post-treatment 4T (31)P-MRS scan using a three-dimensional chemical shift imaging sequence. The extracted brain images were segmented into white matter (WM), gray matter (GM) and CSF. A linear mixed effects model analyzed the effects of pre-treatment and post-treatment depression on phosphorus metabolite concentration estimates (including calculated pH and Mg(++)).For each metabolite, the peak area was normalized by the total phosphorous signal. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Geriatric depression; Geriatric depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 18 |
Sample size | 23 |
Tissue | Central; Brain; Brain; |
Platform | MRS; MRS: 4 T MRI; |
PMID | |
DOI | |
Citation | Forester BP, Harper DG, Jensen JE, et al. 31Phosphorus magnetic resonance spectroscopy study of tissue specific changes in high energy phosphates before and after sertraline treatment of geriatric depression. Int J Geriatr Psychiatry 2009;24(8):788-97. |
Metabolite |
