Study M265
Study name | Chen CS 2009 |
Title | Proton magnetic resonance spectroscopy of late-life major depressive disorder |
Overall design | The aim of this study was to examine the biochemical abnormalities of late-life major depression by using 3-tesla (3-T) proton magnetic resonance spectroscopy (1H-MRS). The antidepressant effects on the biochemical abnormalities were investigated as well. Study participants were elderly patients with major depressive disorders (depression group, n = 27) and comparison elderly subjects (control group, n = 19). The depression group was divided into unmedicated depression group (n = 18) and medicated depression group (n = 9). 1H-MRS spectra were acquired from voxels that were placed in the left frontal white matter, left periventricular white matter, and left basal ganglia. Ratios of N-acetylaspartate (NAA), choline (Cho) and myo-inositol to creatine were calculated. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Geriatric depression; Geriatric depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 15 |
Sample size | 46 |
Tissue | Central; Brain; Periventricular white matter; Central; Brain; Basal ganglia; Central; Brain; Frontal white matter; |
Platform | MRS; MRS: 3 T Signa system (GE Medical Systems, Milwaukee, WI, USA); |
PMID | |
DOI | |
Citation | Chen CS, Chiang IC, Li CW, et al. Proton magnetic resonance spectroscopy of late-life major depressive disorder. Psychiatry Res 2009;172(3):210-4. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
