Study M264
Study name | Block W 2009 |
Title | Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response |
Overall design | In this study, proton magnetic resonance spectroscopy (1H-MRS) of the hippocampus was at performed 3 T in unmedicated subjects with unipolar major depressive episodes (depression group, n = 18) and in age- and gender-matched healthy volunteers (control group, n = 10). Thirteen patients underwent a second examination after 8 wk treatment with either citalopram (n = 7) or nortriptyline (n = 6). Of these patients, 11 MRS datasets could be used for the assessment of treatment correlates. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 28 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 3 T whole-body MR system (Gyroscan Achieva 3.0 T, Philips Medical Systems, Best, The Netherlands); |
PMID | |
DOI | |
Citation | Block W, Traber F, von Widdern O, et al. Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response. Int J Neuropsychopharmacol 2009;12(3):415-22. |
Metabolite | (Glutamate and Glutamine and GABA)/(Creatine and Phosphocreatine) ratio; |
