Study M263

Study name

Xu QG 2008

Title

Metabolic changes of prefrontal cerebral lobe, white matter and cerebellum in patients with post-stroke depression: a proton magnetic resonance spectroscopy study

Overall design

The aim of this study was to investigate changes in N-acetyl-aspartate (NAA), choline (Cho), creatine (Cr), and myoinositol (MI) in the gray and white matter of cerebral prefrontal lobe and cerebellum of patients with differential degrees of post-stroke depression (PSD) using 1H-MRS. A total of 38 patients with stroke were selected. All subjects met the DSM-IV criteria for cerebrovascular disease and depression (post-stroke depression). The degree of depression was defined according to Hamilton criteria. 38 patients with PSD were divided into two groups according to the time after ischemia, 20 patients in the acute group with less than 10 days after ischemic attack (mild: 16 patients, moderate/severe: 4 patients) and 18 patients in the chronic group with more than 11 days after ischemic attack (mild: 15 patients, moderate/severe: 3 patients). Healthy volunteers with matching age from 41 to 80 years were examined as a control group (control group, n = 17). Spectra were acquired by multi-voxel point-resolved spectroscopy (PRESS) sequence with GE signa 1.5T MR/i, localized in prefrontal cerebral lobe and cerebellum. Values of NAA, Cho, MI, and Cr ere compared between different graded PSD patients and control subjects. Both mean absolute levels and mean ratios of metabolite to total creatine levels were compared.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Post-stroke depression; Post-stroke depression;

Criteria for depression

DSM-IV diagnosed MDD

Sample size

55

Tissue

Central; Brain; Cerebellum;

Central; Brain; Prefrontal lobe;

Platform

MRS; MRS: 1.5 T GE scanner (Sigma);

PMID

N/A

DOI

N/A

Citation

Xu QG, Cao H, Song QW, et al. Metabolic changes of prefrontal cerebral lobe, white matter and cerebellum in patients with post-stroke depression: a proton magnetic resonance spectroscopy study. Neural Regen Res 2008;3(2):142-7.

Metabolite

Choline-containing compounds/(Creatine and Phosphocreatine) ratio;