Study M261
Study name | Lin T 2008 |
Title | [A 1H magnetic resonance spectroscopy study on hippocampus of patients with first-episode major depressive disorder] |
Overall design | The aim of this study was to explore the feature of proton magnetic resonance spectroscopy (1H MRS) testing in hippocampus of patients with first-episode major depressive disorder (MDD). 1H MRS was performed on patients suffering from first-episode MDD without antidepressant medication (depression group, n = 21) and matched healthy controls (control group, n = 14) to measure N-acetylaspartate (NAA), Choline (Cho) and creatine (Cr),and to calculate the ratios of NAA/Cr and Cho/Cr. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-24 > 20 |
Sample size | 35 |
Tissue | Central; Brain; Hippocampus; |
Platform | MRS; MRS: 1.5 T Magnet Superconductive Imaging System (Siemens); |
PMID | |
DOI | |
Citation | Lin T, Han HB, Cai ZJ. [A 1H magnetic resonance spectroscopy study on hippocampus of patients with first-episode major depressive disorder]. Chinese Mental Health Journal 2008;22(2):105-8. (Article in Chinese) |
Metabolite |
