Study M259

Study name

Gao CG 2008

Title

[1H-MRS in bilaterlis frontal lobe and hippocampus of patients with first episode major depression after SSRIs antidepressant treatment]

Overall design

The aim of this study was to measure neuro-biochemical changes in brain of first episode major depression (MD) patients. Single-voxel proton magnetic resonance spectroscopic (1H-MRS) examination of bilateralis frontal lobe and hippocampus was conducted in first episode major depression patients (depression group, n = 21) and age-, sex-and education-matched healthy controls (control group, n = 21). After this, major depression patients took selectivity serotonin reuptake inhibitors (SSRIs, 5 for fluoxetine and 16 for paroxetine) for three months. Then, we examined the changes in N-acetyl-aspartate (NAA), choline-containing compounds (Cho), creatine and phosphocreatine (Cr), glutamate and glutamine (Glx), and myo-inositol (mI) in bilaterlis frontal lobe and hippocampus of patients. Finally, we compared the metabolism of the subjects with that of the controls. Metabolite quantification was reported relative to total creatine as the reference peak.

Study Type

Type1;

Type2;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD, HAMD-17 > 17

Sample size

42

Tissue

Central; Brain; Frontal lobe;

Central; Brain; Hippocampus;

Platform

MRS; MRS: Philips gyroscan intera 1.5 T Superconductive Imaging System;

PMID

N/A

DOI

N/A

Citation

Gao CG, Sun Y, Sun QL, et al. [1H-MRS in bilaterlis frontal lobe and hippocampus of patients with first episode major depression after SSRIs antidepressant treatment]. Journal of Xi'an Jiaotong University (Medical Sciences) 2008;29(6):670-3. (Article in Chinese)

Metabolite

N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio;

myo-Inositol/(Creatine and Phosphocreatine) ratio;

(Glutamate and Glutamine)/(Creatine and Phosphocreatine) ratio;