Study M258
Study name | Ajilore O 2007 |
Title | Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy |
Overall design | The aim of this study was to examine the biochemical basis of depression in patients with type 2 diabetes using proton magnetic resonance spectroscopy (MRS). Patients with type 2 diabetes and major depression (diabetes with depression group, n = 20) were scanned along with patients with diabetes alone (diabetes without depression group, n = 24) and healthy controls (control group, n = 21) on a 1.5 T MRI/MRS scanner. Voxels were placed bilaterally in dorsolateral white matter and the subcortical nuclei region, both areas important in the circuitry of late-life depression. Absolute values of myoinositol, creatine, N-acetyl aspartate, glutamate, glutamine, and choline corrected for CSF were measured using the LC-Model algorithm. Metabolite quantification was reported in absolute concentrations. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression with comorbidity; Depression with comorbidity; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 15 |
Sample size | 65 |
Tissue | Central; Brain; Dorsolateral white matter; Central; Brain; Subcortical nuclei; |
Platform | MRS; MRS: GE 1.5 T MRI/MRS scanner (General Electric Medical Systems, Waukesha, WI); |
PMID | |
DOI | |
Citation | Ajilore O, Haroon E, Kumaran S, et al. Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy. Neuropsychopharmacology 2007;32(6):1224-31. |
Metabolite | L-Glutamic acid; L-Glutamine; Glutamate and Glutamine; (Glutamate and Glutamine)/(Creatine and Phosphocreatine) ratio; |
