Study M257
Study name | Mu J 2007a |
Title | 1H magnetic resonance spectroscopy study of thalamus in treatment resistant depressive patients |
Overall design | The aim of this study was to examine possible alterations of thalamus metabolism in adult treatment resistant depressive patients (depression group, n = 20) using 1.5 T 1H magnetic resonance spectroscopy (1H MRS). The treatment resistance was defined as failure to respond to two different antidepressants in adequate dosage for at least a period of 8 weeks. Age- and gender-matched healthy controls (control group, n = 20) were enrolled. Metabolite quantification was reported relative to total creatine as the reference peak. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Treatment-resistant depression; Treatment-resistant depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 40 |
Tissue | Central; Brain; Thalamus; |
Platform | MRS; MRS: 1.5 T GE Signa Highspeed Superconductive Imaging System (General Electric Medical Systems); |
PMID | |
DOI | |
Citation | Mu J, Xie P, Yang ZS, et al. 1H magnetic resonance spectroscopy study of thalamus in treatment resistant depressive patients. Neurosci Lett 2007;425(1):49-52. |
Metabolite | N-Acetyl aspartate/(Creatine and Phosphocreatine) ratio; Choline-containing compounds/(Creatine and Phosphocreatine) ratio; |
