Study M256
Study name | Luborzewski A 2007 |
Title | Metabolic alterations in the dorsolateral prefrontal cortex after treatment with high-frequency repetitive transcranial magnetic stimulation in patients with unipolar major depression |
Overall design | The aim of the present study is to investigate the levels of glutamate, choline compounds, N-acetylaspartate and total creatine (creatine + creatine phosphate) in the left anterior cingulate cortex (ACC) and the left dorsolateral prefrontal cortex (DLPFC) in patients with major depression, before and after a series of 10 consecutive sessions of high-frequency (20 Hz) repetitive transcranial magnetic stimulation (rTMS), and to investigate the relationship between metabolic changes and clinical features of these individuals. Seventeen patients with unipolar major depression were recruited. After 10 days of rTMS, 6 out of seventeen patients were treatment responders (rTMS-treated responder group), defined as a 50% reduction of the Hamilton depression rating scale, and the others were treatment non-responders (rTMS-treated non-responder group). Metabolite quantification was normalized to phantom. |
Study Type | Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD |
Sample size | 17 |
Tissue | Central; Brain; Dorsolateral prefrontal cortex; Central; Brain; Anterior cingulate cortex; |
Platform | MRS; MRS: 3-Tesla scanner (MEDSPEC 30/100, Bruker Biospin, Ettlingen, Germany); |
PMID | |
DOI | |
Citation | Luborzewski A, Schubert F, Seifert F, et al. Metabolic alterations in the dorsolateral prefrontal cortex after treatment with high-frequency repetitive transcranial magnetic stimulation in patients with unipolar major depression. J Psychiatr Res 2007;41(7):606-15. |
Metabolite |
